Click the opposition names to see the Blues' Line-up for the match. For the full fixture list please see evertonfc.com
| Date | Opposition | H/A | Result | Scorers | Attendance |
|---|---|---|---|---|---|
| Jul 10 | Bury (F) | A | 1-2 | Saha 23 | |
| Jul 18 | Rochdale (F) | A | 4-1 | Duffy 7 Dawson (og)24 Jo 32,78 | |
| Jul 26 | River Plate (F) | N | 0-1 | ||
| Jul 30 | MLS All Stars (F) | A | 1-1 6-5 pens | Saha 12 | |
| Aug 2 | Coventry City (F) | A | 2-2 | Cahill 16 Baxter 85 | |
| Aug 4 | Bury (F) | A | 1-2 | Jo 19 | |
| Aug 7 | Malaga CF (F) | H | 2-1 | Saha 15 Osman 20 | 20,854 |
| Aug 15 | Arsenal | H | 1-6 | Saha 90 | 39,309 |
| Aug 20 | SK Sigma Olomouc (EL) | H | 4-0 | Saha 32,72 Rodwell 39,53 | 27, 433 |
| Aug 23 | Burnley | A | 0-1 | ||
| Aug 27 | SK Sigma Olomouc (EL) | A | 1-1 | Pienaar 42 | |
| Aug 30 | Wigan Athletic | H | 2-1 | Saha 61 Baines (pen)90 | 35,122 |
| Sep 13 | Fulham | A | 1-2 | Cahill 32 | |
| Sep 17 | AEK Athens (EL) | H | 4-0 | Yobo 9 Distin 16 Pienaar 36 Jo 81 | 26,747 |
| Sep 20 | Blackburn Rovers | H | 3-0 | Saha 21,53 Yobo 57 | 35,546 |
| Sep 23 | Hull City (CC) | A | 4-0 | Yakubu 10 Jo 19 Gosling 23 Osman 56 | |
| Sep 26 | Portsmouth | A | 1-0 | Saha 41 | |
| Oct 1 | BATE Borisov (EL) | A | 2-1 | Fellaini 67 Cahill 76 | |
| Oct 4 | Stoke City | H | 1-1 | Osman 54 | 36,753 |
| Oct 17 | Wolverhampton Wanderers | H | 1-1 | Bilyaletdinov 87 | 39,319 |
| Oct 22 | SL Benfica (EL) | A | 0-5 | ||
| Oct 25 | Bolton Wanderers | A | 2-3 | Saha 31 Fellaini 54 | |
| Oct 27 | Tottenham Hotspur (CC) | A | 0-2 | ||
| Oct 31 | Aston Villa | H | 1-1 | Bilyaletdinov 45 | 36,648 |
| Nov 5 | SL Benfica (EL) | H | 0-2 | 30,790 | |
| Nov 8 | West Ham United | A | 2-1 | Saha 26 Gosling 63 | |
| Nov 21 | Manchester United | A | 0-3 | ||
| Nov 25 | Hull City | A | 2-3 | Zayatte (og)49 Saha 65 | |
| Nov 29 | Liverpool | H | 0-2 | 39,652 | |
| Dec 2 | AEK Athens (EL) | A | 1-0 | Bilyaltedinov 6 | |
| Dec 6 | Tottenham Hotspur | H | 2-2 | Saha 77 Cahill 85 | 34,003 |
| Dec 12 | Chelsea | A | 3-3 | Cech (og)12 Yakubu 45 Saha 63 | |
| Dec 17 | BATE Borisov (EL) | H | 0-1 | 18,242 | |
| Dec 20 | Birmingham City | H | 1-1 | Bilyaletdinov 5 | 33,660 |
| Dec 26 | Sunderland | A | 1-1 | Fellaini 85 | |
| Dec 28 | Burnley | H | 2-0 | Vaughan 83 Pienaar 90 | 39,419 |
| Jan 2 | Carlisle United (FA) | H | 3-1 | Vaughan 12 Cahill 82 Baines (pen)90 | 31,196 |
| Jan 9 | Arsenal | A | 2-2 | Osman 12 Pienaar 81 | |
| Jan 16 | Manchester City | H | 2-0 | Pienaar 36 Saha (pen)45 | 37,378 |
| Jan 23 | Birmingham City (FA) | H | 1-2 | Osman 56 | 30,875 |
| Jan 27 | Sunderland | H | 2-0 | Cahill 7 Donovan 19 | 32,163 |
| Jan 30 | Wigan Athletic | A | 1-0 | Cahill 84 | |
| Feb 6 | Liverpool | A | 0-1 | ||
| Feb 10 | Chelsea | H | 2-1 | Saha 33,75 | 36,411 |
| Feb 16 | Sporting Lisbon (EL) | H | 2-1 | Pienaar 35 Distin 49 | 28,131 |
| Feb 20 | Manchester United | H | 3-1 | Bilyaletdinov 19 Gosling 76 Rodwell 90 | 39,448 |
| Feb 25 | Sporting Lisbon (EL) | A | 0-3 | ||
| Feb 28 | Tottenham Hotspur | A | 1-2 | Yakubu 55 | |
| Mar 7 | Hull City | H | 5-1 | Arteta 17,39 Garcia (og)51 Donovan 82 Rodwell 86 | 34,682 |
| Mar 13 | Birmingham City | A | 2-2 | Anichebe 19 Yakubu 22 | |
| Mar 20 | Bolton Wanderers | H | 2-0 | Arteta 72 Pienaar 89 | 36,503 |
| Mar 24 | Manchester City | A | 2-0 | Cahill 33 Arteta 85 | |
| Mar 27 | Wolverhampton Wanderers | A | 0-0 | ||
| Apr 4 | West Ham United | H | 2-2 | Bilyaletdinov 23 Yakubu 84 | 37,451 |
| Apr 14 | Aston Villa | A | 2-2 | Cahill 23,74 | |
| Apr 17 | Blackburn Rovers | A | 3-2 | Arteta (pen)4 Yakubu 79 Cahill 90 | |
| Apr 25 | Fulham | H | 2-1 | Smalling (og)49 Arteta (pen)90 | 35,578 |
| May 1 | Stoke City | A | 0-0 | ||
| May 9 | Portsmouth | H | 1-0 | Bilyaletdinov 90 | 38,730 |