Click the opposition names to see the Blues' Line-up for the match. For the full fixture list please see evertonfc.com
| Date | Opposition | H/A | Result | Scorers | Attendance |
|---|---|---|---|---|---|
| Jul 14 | FC Sion (F) | A | 0-1 | ||
| Jul 19 | Cambridge United (F) | A | 2-4 | Jutkiewicz 20,30 | |
| Jul 22 | Preston North End (F) | A | 1-0 | Jagielka 9 | |
| Jul 25 | Nottingham Forest (F) | A | 1-1 | Baxter 65 | |
| Jul 31 | Chicago Fire (F) | A | 0-2 | ||
| Aug 4 | Colorado Rapids (F) | A | 2-1 | Arteta 6 Osman 87 | |
| Aug 9 | PSV Eindhoven (F) | H | 1-1 | Arteta (pen)85 | 10,816 |
| Aug 16 | Blackburn Rovers | H | 2-3 | Arteta 45 Yakubu 63 | 38,675 |
| Aug 23 | West Bromwich Albion | A | 2-1 | Osman 64 Yakubu 75 | |
| Aug 30 | Portsmouth | H | 0-3 | 34,418 | |
| Sep 14 | Stoke City | A | 3-2 | Yakubu 40 Anichebe 50 Cahill 76 | |
| Sep 18 | Standard Liege (UC) | H | 2-2 | Yakubu 22 Castillo 37 | 28,312 |
| Sep 21 | Hull City | A | 2-2 | Cahill 72 Osman 77 | |
| Sep 24 | Blackburn Rovers (CC) | A | 0-1 | ||
| Sep 27 | Liverpool | H | 0-2 | 39,574 | |
| Oct 2 | Standard Liege (UC) | A | 1-2 | Jagielka 66 | |
| Oct 5 | Newcastle United | H | 2-2 | Arteta (pen)17 Fellaini 35 | 33,805 |
| Oct 18 | Arsenal | A | 1-3 | Osman 9 | |
| Oct 25 | Manchester United | H | 1-1 | Fellaini 62 | 36,069 |
| Oct 29 | Bolton Wanderers | A | 1-0 | Fellaini 89 | |
| Nov 1 | Fulham | H | 1-0 | Saha 87 | 31,278 |
| Nov 8 | West Ham United | A | 3-1 | Lescott 82 Saha 84,86 | |
| Nov 16 | Middlesbrough | H | 1-1 | Yakubu 64 | 31,063 |
| Nov 24 | Wigan Athletic | A | 0-1 | ||
| Nov 30 | Tottenham Hotspur | A | 1-0 | Corluka (og)51 | |
| Dec 7 | Aston Villa | H | 2-3 | Lescott 30,90 | 31,922 |
| Dec 13 | Manchester City | A | 1-0 | Cahill 90 | |
| Dec 22 | Chelsea | H | 0-0 | 35,655 | |
| Dec 26 | Middlesbrough | A | 1-0 | Cahill 51 | |
| Dec 28 | Sunderland | H | 3-0 | Arteta 10 Collins (og)27 Gosling 83 | 39,146 |
| Jan 3 | Macclesfield (FA) | A | 1-0 | Osman 42 | |
| Jan 10 | Hull City | H | 2-0 | Fellaini 18 Arteta 45 | 37,527 |
| Jan 19 | Liverpool | A | 1-1 | Cahill 86 | |
| Jan 25 | Liverpool (FA) | A | 1-1 | Lescott 26 | |
| Jan 28 | Arsenal | H | 1-1 | Cahill 60 | 37,097 |
| Jan 31 | Manchester United | A | 0-1 | ||
| Feb 4 | Liverpool (FA) | H | 1-0 AET | Gosling 117 | 37,918 |
| Feb 7 | Bolton Wanderers | H | 3-0 | Arteta (pen)39 Jo 48,(pen)90 | 33,791 |
| Feb 15 | Aston Villa (FA) | H | 3-1 | Rodwell 3 Arteta (Pen)23 Cahill 75 | 32,979 |
| Feb 22 | Newcastle United | A | 0-0 | ||
| Feb 28 | West Bromwich Albion | H | 2-0 | Cahill 36 Saha 70 | 33,898 |
| Mar 4 | Blackburn Rovers | A | 0-0 | ||
| Mar 8 | Middlesbrough (FA) | H | 2-1 | Fellaini 50 Saha 56 | 37,856 |
| Mar 14 | Stoke City | H | 3-1 | Jo 18 Lescott 24 Fellaini 90 | 36,396 |
| Mar 21 | Portsmouth | A | 1-2 | Baines 4 | |
| Apr 5 | Wigan Athletic | H | 4-0 | Jo 26,51 Fellaini 47 Osman 61 | 34,427 |
| Apr 12 | Aston Villa | A | 3-3 | Fellaini 18 Cahill 22 Pienaar 52 | |
| Apr 19 | Manchester United (FA) | N | 0-0 AET 4-2 pens | ||
| Apr 22 | Chelsea | A | 0-0 | ||
| Apr 25 | Manchester City | H | 1-2 | Gosling 90 | 37,791 |
| May 3 | Sunderland | A | 2-0 | Pienaar 47 Fellaini 70 | |
| May 9 | Tottenham Hotspur | H | 0-0 | 36,646 | |
| May 16 | West Ham United | H | 3-1 | Saha (pen)38,76 Yobo 48 | 38,501 |
| May 24 | Fulham | A | 2-0 | Osman 44,87 | |
| May 30 | Chelsea (FA) | N | 1-2 | Saha 1 |