Click the opposition names to see the Blues' Line-up for the match. For the full fixture list please see evertonfc.com
| Date | Opposition | H/A | Result | Scorers | Attendance |
|---|---|---|---|---|---|
| Jul 14 | Bury (F) | A | 1-0 | Jutkiewicz 56 | |
| Jul 14 | Northern Ireland Select (F) | A | 2-0 | Vaughan 27 Agard 79 | |
| Jul 18 | Preston North End (F) | A | 1-1 | Anichebe 80 | |
| Jul 22 | Real Salt Lake (F) | A | 0-2 | ||
| Jul 31 | Werder Bremen (F) | H | 2-2 | McFadden 74 Anderson 86 | 12,144 |
| Aug 4 | Crystal Palace (F) | A | 0-0 | ||
| Aug 11 | Wigan Athletic | H | 2-1 | Osman 25 Anichebe 74 | 39,220 |
| Aug 14 | Tottenham Hotspur | A | 3-1 | Lescott 3 Osman 37 Stubbs 45 | |
| Aug 18 | Reading | A | 0-1 | ||
| Aug 25 | Blackburn Rovers | H | 1-1 | McFadden 77 | 33,850 |
| Sep 1 | Bolton Wanderers | A | 2-1 | Yakubu 10 Lescott 89 | |
| Sep 15 | Manchester United | H | 0-1 | 39,364 | |
| Sep 20 | Metalist Kharkiv (UC) | H | 1-1 | Lescott 24 | 37,120 |
| Sep 23 | Aston Villa | A | 0-2 | ||
| Sep 26 | Sheffield Wednesday (CC) | A | 3-0 | McFadden 58,83 Yakubu 84 | |
| Sep 15 | Middlesbrough | H | 2-0 | Lescott 6 Pienaar 57 | 31,885 |
| Oct 4 | Metalist Kharkiv (UC) | A | 3-2 | Lescott 47 McFadden 71 Anichebe 87 | |
| Oct 7 | Newcastle United | A | 2-3 | Johnson 52 Given (og)90 | |
| Oct 20 | Liverpool | H | 1-2 | Hyppia (og)37 | 40,049 |
| Oct 25 | AE Larissa (UC) | H | 3-1 | Cahill 31 Osman 49 Anichebe 89 | 33,777 |
| Oct 28 | Derby County | A | 2-0 | Arteta 25 Yakubu 62 | |
| Oct 31 | Luton Town (CC) | A | 1-0 AET | Cahill 100 | |
| Nov 3 | Birmingham City | H | 3-1 | Yakubu 9 Carsley 90 Vaughan 90 | 35,155 |
| Nov 8 | FC Nürnberg (UC) | A | 2-0 | Arteta (pen)82 Anichebe 87 | |
| Nov 11 | Chelsea | A | 1-1 | Cahill 89 | |
| Nov 24 | Sunderland | H | 7-1 | Yakubu 11,72 Cahill 16,61 Pienaar 42 Johnson 79 Osman 84 | 38,594 |
| Dec 1 | Portsmouth | A | 0-0 | ||
| Dec 5 | Zenit Peterburg (UC) | H | 1-0 | Cahill 84 | 38,407 |
| Dec 8 | Fulham | H | 3-0 | Yakubu 50,60,78 | 32,743 |
| Dec 12 | West Ham United (CC) | A | 2-1 | Osman 39 Yakubu 87 | |
| Dec 15 | West Ham United | A | 2-0 | Yakubu 45 Johnson 90 | |
| Dec 20 | AZ Alkmaar (UC) | A | 3-2 | Johnson 1 Jagielka 43 Vaughan 78 | |
| Dec 23 | Manchester United | A | 1-2 | Cahill 26 | |
| Dec 26 | Bolton Wanderers | H | 2-0 | Neville 50 Cahill 69 | 38,918 |
| Dec 29 | Arsenal | H | 1-4 | Cahill 18 | 39,443 |
| Jan 1 | Middlesbrough | A | 2-0 | Johnson 66 McFadden 71 | |
| Jan 5 | Oldham Athletic (FA) | H | 0-1 | 33,086 | |
| Jan 8 | Chelsea (CC) | A | 1-2 | Yakubu 63 | |
| Jan 12 | Manchester City | H | 1-0 | Lescott 30 | 38,474 |
| Jan 20 | Wigan Athletic | A | 2-1 | Johnson 38 Lescott 41 | |
| Jan 23 | Chelsea (CC) | H | 0-1 | 37,086 | |
| Jan 30 | Tottenham Hotspur | H | 0-0 | 35,840 | |
| Feb 2 | Blackburn Rovers | A | 0-0 | ||
| Feb 9 | Reading | H | 1-0 | Jagielka 61 | 36,582 |
| Feb 13 | SK Brann (UC) | A | 2-0 | Osman 58 Anichebe 87 | |
| Feb 21 | SK Brann (UC) | H | 6-1 | Yakubu 35,53,71 Johnson 40,90 Arteta 69 | 32,834 |
| Feb 25 | Manchester City | A | 2-0 | Yakubu 29 Lescott 37 | |
| Mar 2 | Portsmouth | H | 3-1 | Yakubu 1,80 Cahill 72 | 33.938 |
| Mar 6 | Fiorentina (UC) | A | 0-2 | ||
| Mar 9 | Sunderland | A | 1-0 | Johnson 54 | |
| Mar 12 | Fiorentina (UC) | H | 2-0 2-4 pens | Johnson 15 Arteta 66 | 38,026 |
| Mar 16 | Fulham | A | 0-1 | ||
| Mar 22 | West Ham United | H | 1-1 | Yakubu 7 | 37,430 |
| Mar 30 | Liverpool | A | 0-1 | ||
| Apr 6 | Derby County | H | 1-0 | Osman 55 | 36,017 |
| Apr 12 | Birmingham City | A | 1-1 | Lescott 77 | |
| Apr 17 | Chelsea | H | 0-1 | 37,112 | |
| Apr 27 | Aston Villa | H | 2-2 | Neville 55 Yobo 83 | 37,936 |
| May 4 | Arsenal | A | 0-1 | ||
| May 11 | Newcastle United | H | 3-1 | Yakubu 27, (pen)81 Lescott 69 | 39,592 |