Click the opposition names to see the Blues' Line-up for the match. For the full fixture list please see evertonfc.com
| Date | Opposition | H/A | Result | Scorers | Attendance |
|---|---|---|---|---|---|
| Jul 15 | Bury (F) | A | 3-1 | Anichebe 9,63 Arteta 22 | |
| Jul 15 | Port Vale (F) | A | 2-0 | McFadden 65 Kilbane 64 | |
| Jul 19 | Preston North End (F) | A | 0-0 | ||
| Jul 23 | Celtic (F) | A | 0-1 | ||
| Jul 26 | Columbus Crew (F) | A | 1-1 | Anichebe 33 | |
| Jul 29 | Club America (F) | N | 1-1 4-5 pens | Arteta 5 | |
| Aug 8 | Aberdeen (F) | A | 3-2 | Beattie 53 Cahill 85 Anichebe 90 | |
| Aug 12 | Athletic Bilbao (F) | H | 0-1 | 17,868 | |
| Aug 19 | Watford | H | 2-1 | Johnson 14 Arteta (pen)81 | 39,691 |
| Aug 23 | Blackburn Rovers | A | 1-1 | Cahill 83 | |
| Aug 26 | Tottenham Hotspur | A | 2-0 | Davenport (og)53 Johnson 65 | |
| Sep 9 | Liverpool | H | 3-0 | Cahill 23 Johnson 35,90 | 40,004 |
| Sep 16 | Wigan Athletic | H | 2-2 | Johnson 48 Beattie (pen)65 | 37,117 |
| Sep 19 | Peterborough United (CC) | A | 2-1 | Stirling (og)23 Cahill 86 | |
| Sep 24 | Newcastle United | A | 1-1 | Cahill 40 | |
| Sep 30 | Manchester City | H | 1-1 | Johnson 43 | 38,250 |
| Oct 14 | Middlesbrough | A | 1-2 | Cahill 76 | |
| Oct 21 | Sheffield United | H | 2-0 | Arteta 12 Beattie (pen)32 | 37,900 |
| Oct 24 | Luton Town (CC) | H | 4-0 | Cahill 22 Keane (og)33 McFadden 52 Anichebe 82 | 27,149 |
| Oct 28 | Arsenal | A | 1-1 | Cahill 10 | |
| Nov 4 | Fulham | A | 0-1 | ||
| Nov 8 | Arsenal (CC) | H | 0-1 | 31,045 | |
| Nov 11 | Aston Villa | H | 0-1 | 36,376 | |
| Nov 18 | Bolton Wanderers | H | 1-0 | Arteta 59 | 34,417 |
| Nov 25 | Charlton Athletic | A | 1-1 | Hreidarsson (og)51 | |
| Nov 29 | Manchester United | A | 0-3 | ||
| Dec 3 | West Ham United | H | 2-0 | Osman 50 Vaughan 90 | 32,968 |
| Dec 9 | Portsmouth | A | 0-2 | ||
| Dec 17 | Chelsea | H | 2-3 | Arteta (pen)37 Yobo 63 | 33,970 |
| Dec 23 | Reading | A | 2-0 | Johnson 13 McFadden 46 | |
| Dec 26 | Middlesbrough | H | 0-0 | 38,126 | |
| Dec 30 | Newcastle United | H | 3-0 | Anichebe 8,57 Neville 61 | 38,682 |
| Jan 1 | Manchester City | A | 1-2 | Osman 83 | |
| Jan 7 | Blackburn Rovers (FA) | H | 1-4 | Johnson (pen)68 | 24,426 |
| Jan 14 | Reading | H | 1-1 | Johnson 80 | 34,722 |
| Jan 21 | Wigan Athletic | A | 2-0 | Arteta (pen)64,90 | |
| Jan 27 | AFC Bournemouth (F) | A | 1-1 | Vidarsson 80 | |
| Feb 3 | Liverpool | A | 0-0 | ||
| Feb 10 | Blackburn Rovers | H | 1-0 | Johnson 9 | 35,593 |
| Feb 21 | Tottenham Hotspur | H | 1-2 | Arteta 42 | 34,121 |
| Feb 24 | Watford | A | 3-0 | Fernandes 22 Johnson (pen)24 Osman 90 | |
| Mar 3 | Sheffield United | A | 1-1 | Arteta (pen)74 | |
| Mar 18 | Arsenal | H | 1-0 | Johnson 90 | 37,162 |
| Apr 2 | Aston Villa | A | 1-1 | Lescott 14 | |
| Apr 6 | Fulham | H | 4-1 | Carsley 24 Stubbs 33 Vaughan 44 Anichebe 79 | 35,612 |
| Apr 9 | Bolton Wanderers | A | 1-1 | Vaughan 33 | |
| Apr 15 | Charlton Athletic | H | 2-1 | Lescott 80 McFadden 90 | 34,028 |
| Apr 21 | West Ham United | A | 0-1 | ||
| Apr 28 | Manchester United | H | 2-4 | Stubbs 11 Fernandes 49 | 39,682 |
| May 5 | Portsmouth | H | 3-0 | Arteta (pen)58 Yobo 61 Naysmith 90 | 39,619 |
| May 13th | Chelsea | A | 1-1 | Vaughan 50 |